Aegle Therapeutics is developing novel therapies using extracellular vesicles (EVs) isolated from mesenchymal stem cells (MSCs) to deliver therapeutic biomolecules to diseased and damaged cells to treat disorders with significant unmet medical need.
EVs are the body’s courier service. MSCs, like all cells, package cell specific cargo into membrane bound EVs and then release the EVs. MSC-EVs travel in the intracellular space or in the bloodstream to recipient cells, delivering contents such as nucleic acids, proteins and immunomodulatory agents. These EVs naturally and efficiently transfer their cargo to target cells and are capable of altering cell function and/or reprogramming cells. They have also been shown to be involved in cell-to-cell communication. Aegle’s patented EV harvesting technology, exclusively licensed from the University of Miami, allows us to gently isolate EVs from MSCs without damaging or modifying the EVs. Aegle’s composite of MSC-EVs has the potential to treat a broad range of indications in multiple therapeutic areas, including dermatology, immunology-based diseases, protein deficient disorders and many others.
The lead indication for our product AGLE-102TM is dystrophic epidermolysis bullosa (DEB), a rare, pediatric disease resulting in severe skin blistering from minor friction, which causes disfigurement, extraordinary pain, and a shortened life span. AGLE-102 provides a unique, multifaceted approach to the treatment of this monogenetic disease in which patients cannot make the protein collagen VII (COL7). Data from preclinical studies demonstrated that AGLE-102 induces recessive DEB fibroblasts (deficient in COL7) to produce COL7. In addition, AGLE-102 has the potential to deliver COL7 protein as well as other cargo important for the functional regeneration and organization of complex tissue structures that may reduce inflammation, accelerate/enhance healing, reduce scarring, and improve overall cosmesis in DEB patients.
Mesenchymal stem cell (red) secreting extracellular vesicles (red) which fuse into the neighboring fibroblast (green) to deliver their cargo. Nuclei are in blue.