In 2015, the American Burn Association estimated that approximately 486,000 patients receive hospital and emergency room treatment for burns each year. Hospitalizations related to burn injuries were estimated at 50,000 with treatments cost of more than $10.4 billion per year (in 2010 dollars). Complications associated with burn injuries can arise despite early burn management, and when they do treatment costs grow exponentially. Even low-intensity treatment for moderate burns may cost $206,853 or more if there are complications. For severe burns treated without complications, the average cost is greater than $1.6 million. With complications, a severe burn can cost more than $10 million to treat successfully.

Burns typically occur in younger victims such as public safety workers, soldiers and children For example, wounded veterans suffer lifelong disabilities from these injuries.

In spite of advancements in medicine, there remains a significant need to improve the healing of burns, as well as the reduction of disfiguring scarring and complications. The productivity losses due to burns were almost $5 billion in 2000 or $8.6 billion in 2010 dollars. An additional burden of wound healing is the problem of scarring, a $12 billion annual market.