Research has shown that extracellular vesicles play a critical role in intercellular communication, and can act locally and distally within the body. They are able to induce changes in cells by fusing with a target cell and introducing the molecules transported on and/or in the extracellular vesicle to the target cell. They are believed to play a critical role in maintaining health and healing.
Extracellular Vesicle Therapy vs. Stem Cell Therapy
Aegle Therapeutics’ scientists have been conducting research using stem cells and stem cell therapy for over 20 years. As a result, they (and others) discovered that extracellular vesicles secreted by adult human stem cells function as the critical mediators by which cells promote healing. Like stem cells, extracellular vesicles stimulate and enhance neuronal regeneration, cellular proliferation, cellular migration, and functional regeneration and organization of complex tissue structures. However, extracellular vesicles are not cells. The use of extracellular vesicles eliminates issues and risks associated with stem cell therapy including: 1.) the high cost of preparation; 2.) cellular delivery, including development of unwanted cell types; 3.) culture-induced senescence; 4.) loss of functional properties; 5.) genetic instability, and/or 6.) eventual malignant formation.
Additionally, extracellular vesicles are stable and do not require specialized handling. They can be scaled for volume production at a low cost and can be stored for extensive periods of time.